Do not confuse gluconolactone with glucuronolactone.

Being part of the poly-hydroxy acids (P.H.A), the gluconolactone is an organic acid used as a cosmetic active ingredient, but also in food as an additive. Gluconolactone, also known as glucono-delta-lactone, is naturally found in nature and in certain foods such as honey.

Gluconolactone presents itself as a crystalline, odourless white powder. It transforms into gluconic acid when it comes into contact with the moisture of the skin. Its application results in a keratolytic effect, meaning it eliminates dead cells on the skin's surface by disrupting the cohesion between corneocytes.

This active ingredient is also interesting due to its moisturising properties, which allow it to strengthen the hydrolipidic barrier. This is possible due to the presence of numerous hydroxyl functions (OH) in the chemical structure of gluconolactone. These hydroxyl functions establish hydrogen bonds with water, which reduces transepidermal water loss.

It also possesses antioxidant properties that protect the skin from external aggressions and fight against free radicals, which are responsible for signs of ageing.

Compared to alpha-hydroxy acids (A.H.A), polyhydroxy acids (P.H.A.) are gentler. Indeed, they have a higher molecular weight and therefore penetrate less deeply into the skin. As a result, they are well tolerated by sensitive skin.

Glucuronolactone or gamma-glucuronic acid lactone is a sugar naturally found in the body. It can be of plant origin or obtained by oxidising starch using nitric acid. This ingredient is primarily incorporated into energy drinks. Its effect is similar to that of caffeine, helping to combat fatigue and promote a sense of well-being.

At Typology, we have various products based on gluconolactone :

• The peeling mask unclogs pores, renews the skin, and evens out the complexion. Composed of an exfoliating complex based on A.H.A. and P.H.A., it eliminates dead skin cells and refines the skin's texture. Applied once or twice a week, it also helps to reduce the presence of blackheads over time. However, due to its high concentration of A.H.A., its application is not recommended for sensitive skin.

• The anti-mark serum :

  Thanks to gluconolactone, which promotes the removal of dead skin cells, this serum reduces the appearance of hyperpigmented post-acne marks (in conjunction with liquorice extract which decreases melanin production) and hypertrophic scars. Owing to its moisturising properties, it will help the skin maintain its hydration and thus reduce the risk of skin dryness. This serum also contains Centella asiatica, which is a powerful healing, soothing and anti-inflammatory active ingredient. This serum is used topically, preferably in the evening.

• The exfoliating cleansing gel :

  This is a cleansing treatment designed to remove impurities, excess sebum, and pollution residues accumulated on the epidermis. The gluconolactone contained in the treatment will micro-exfoliate the skin and unclog the pores. It also promotes the skin's natural hydration. The presence of the aloe vera gel helps to hydrate, repair, and soothe the skin. The sweet orange essential oil it contains has antibacterial properties that are ideal for combating spots.

• The scalp exfoliant:

  It provides a dual exfoliation of the scalp: chemical with gluconolactone, and mechanical with jojoba beads and silica powder. The scalp is healthy, rebalanced and freed from dead cells. The mechanical exfoliation action combined with thepeppermint essential oil helps to accelerate hair growth by stimulating microcirculation. Moreover, theeucalyptus globulus essential oilit contains soothes scalp irritations and limits the appearance of dandruff. Finally, gluconolactone and aloe vera stimulate the scalp's natural hydration. This scrub is to be usedonce or twice a week on a dry scalp. Despite the presence of essential oils, this product can be used by pregnant and breastfeeding women.

• KSENZNKO S. M. & al. The polyhydroxy acid gluconolactone provides protection against ultraviolet radiation in an in vitro model of skin photoaging. Dermatological Surgery (2004).

• ROTSZTEJN H. & al. Evaluation of skin moisture using corneometry after application of 10% and 30% gluconolactone. Skin ResearchandTechnology (2021).