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Acide hyaluronique hydratant

Hyaluronic acid, a source of hydration.

A molecule well-known to cosmetic enthusiasts, hyaluronic acid is often cited as a benchmark for hydration. How do the hydrating properties of hyaluronic acid actually work? And what does the scientific literature say? More details in this article.

Published June 14, 2024, by Pauline, Head of Scientific Communication — 6 min read

How does hyaluronic acid hydrate the skin?

Water is one of the major constituents of our body, accounting for approximately 60% of body weight. In the skin, it is primarily found in the dermis. The hydration of the epidermis, which is essential for its suppleness, softness and appearance, is mainly governed by mechanisms of diffusion from the dermis and evaporation at the skin's surface. Within the dermis, there is a connective tissue characterised by an abundant extracellular matrix, predominantly composed of protein fibres (collagen and elastin) and glycosaminoglycans, including hyaluronic acid. Together, they form a compressible gel that retains water like a sponge, also facilitating its circulation and that of dissolved molecules. While hyaluronic acid is primarily present in the dermis, recent histological studies have shown that it also exists in the epidermis, where it binds water molecules that are then retained by the hydrolipidic film.

Hyaluronic acid is the key molecule for skin hydration and is capable of attracting and retaining up to 1000 times its weight in water.

The highly hygroscopic nature of the hyaluronic acid, combined with its healing and anti-inflammatory properties, makes it an interesting active ingredient to use in cosmetics. There are several forms of hyaluronic acid that can penetrate the skin to varying depths. When it is of high molecular weight (1000 - 1400 kDa), hyaluronic acid remains on the surface of the epidermis where it creates a film limiting the evaporation of water molecules. The low molecular weight active ingredient (20 - 300 kDa), on the other hand, is capable of crossing the horny layer to lodge itself in the deeper layers of the epidermis and retain the water molecules diffused towards the surface.

By ensuring skin hydration, hyaluronic acid strengthens the skin barrier, which slows down the appearance of ageing signs, reduces the risk of infections and promotes the healing process.

Numerous clinical studies have focused on the hydrating power of hyaluronic acid when applied topically. A few of these are gathered in the table below, to more concretely highlight the moisturising properties of this active ingredient.

PAVICIC & al. (2011)Application of a 0.1% hyaluronic acid cream (50, 130, 300, 800 or 2000 kDa) twice daily by 76 volunteersAn average increase in hydration of 10% after 60 days
VEGA & al. (2016)Application of a hyaluronic acid serum twice daily by 24 volunteersAn increase in hydration measured by a corneometer of 13% after 8 weeks
BOYD & al. (2021)Application of a hyaluronic acid serum twice daily by 40 volunteersAn increase in hydration measured with a corneometer of 35% after 2 weeks, 46% after 4 weeks, and 63% after 6 weeks
GIANNINI & al. (2022)Application of a hyaluronic acid serum twice daily by 46 volunteersAn increase in hydration by 11% after 8 weeks

Hyaluronic Acid and Hydration: What are the benefits for hair?

The moisturising virtues of hyaluronic acid can also benefit the hair. Indeed, this active ingredient, which does not leave a greasy effect, can deeply hydrate hair fibres and strengthen the hydrolipidic film present on their surface. This film aims to protect the hair from external aggressions (vigorous brushing, wind, temperature variations...) and to keep them hydrated. By providing protection and hydration to the hair fibres, hyaluronic acid also prevents their breakage and the appearance of split ends, resulting in softer and stronger hair.

Hyaluronic acid treatments are particularly beneficial for dry or damaged hair and this active ingredient is frequently found in conditioners, treatments that protect the hair and make styling easier. A scientific study has indeed focused on the effects of a conditioner containing 1% hyaluronic acid as an active substance. This treatment has been shown to increase the Young's modulus, which quantifies the elasticity of the fibres, by 25%. The thickness of the hair also significantly increased by 6% and the researchers noted an overall improvement in the hydration and appearance of the hair fibres.


  • MAIBACH H. I. & al. Hyaluronan in skin: aspects of ageing and its pharmacological modulation. Clinics in Dermatology (2008).

  • MASSON F. Skin Hydration and Hyaluronic Acid. Annals of Dermatology and Venereology (2010).

  • PAVICIC T. & al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology (2011).

  • PIOT O. & al. Investigation into the penetration of hyaluronic acid of varying molecular weights into human skin, as examined by Raman spectroscopy. Skin Research & Technology (2015).

  • VEGA L. & al. Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Balance with Immediate Advantages. Journal of Drugs in Dermatology (2016).

  • SIONKOWSKA A. & al. The characteristics of hair treated with conditioners containing collagen, chitosan and hyaluronic acid. European Journal of Medical Technologies (2019).

  • BOYD T. & al. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging. Dermatology & Therapy (2021).

  • GIANNINI A. & al. Multicentre evaluation of a topical hyaluronic acid serum. Journal of Cosmetic Dermatology (2022).


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