How does a spot form?

The whiteheads, also known as closed comedones or microcysts are a form of sub-surface pre-acne. They result from an over-secretion of sebum by the sebaceous glands. This excess sebum will block the pores, forming a micro-lesion with a white appearance.

Besides hyperseborrhea, whiteheads also result from hyperkeratinisation of the cells in the follicular canal wall. In other words, the cells multiply excessively, leading to a blockage of the follicular canal, which prevents the elimination of sebum.

Thus, sebum accumulates under the skin and gives rise to a localised and hardened bulge in the skin. Whiteheads can regress spontaneously or become inflamed. They are frequently observed in retentional acne.

Please note : there are also open comedones, but these are not considered as spots. The open comedones or blackheads result from the same process as microcysts. When these blocked pores are open, oxidation occurs upon contact with air and the impurities trapped inside the pore darken, thus forming a blackhead.

The papules are inflammatory skin features characterised by a swelling of solid consistency, that is to say containing neither liquid nor pus, of small size (ranging from 1 to 4 mm) and of a pink to red colour.

Papules are one of the symptoms observed ininflammatory acne. This inflammation is caused by a bacterium: Cutibacterium acnes.

Cutibacterium acnes is a commensal bacterium of the skin microbiota. It contributes to the maintenance of healthy skin balance. However, under certain conditions, Cutibacterium acnes proliferates abnormally and becomes pathogenic.

As mentioned earlier, microcysts, which are the least severe manifestation of acne, can become inflamed. Indeed, microcysts are caused, among other things, by an excess of sebum. This fat-rich environment, promotes the proliferation of Cutibacterium acnes which secretes inflammation mediators. This triggers an inflammatory response on the skin's surface. This bacterium is also responsible for a hyperkeratinisation of the skin (thickening of the skin) which encourages the appearance of blemishes.

The papules observed in inflammatory acne are indicative of a superficial inflammation caused by the proliferation of Cutibacterium acnes.

The pustules are small inflammatory lesions of the skin characterised by a well-defined and circumscribed elevation of the epidermis (diameter less than 5 mm) and topped in their centre by a purulent liquid of white colour or yellow.

Just like papules, pustules are observed in inflammatory acne and are a sign of superficial inflammation.

When inflammation is too severe or lasts too long, a bacterial contamination comes to infect the spot which will fill with pus. In this case, the papule transforms into a pustule.