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What is "Acetyl Tetrapeptide-9" and what is its utility?

What is "Acetyl Tetrapeptide-9" and what is its utility?

Peptides are small molecules that play a role in numerous skin processes. By reducing pigmentation spots and wrinkles, their action helps to maintain skin quality. Among the peptide family is "acetyl tetrapeptide-9". This molecule is used in the composition of creams and serums, as its properties help to firm the contours of the face. Here is everything you need to know about "Acetyl Tetrapeptide-9" and its usefulness.

Acetyl Tetrapeptide-9: What is it?

Peptides are sequences of short or long chain amino acids, the building blocks of proteins. Naturally present in the body, peptides have the unique ability to bind to receptors and trigger metabolic reactions. Thus, these small chains of amino acids stimulate the production of skin proteins such as collagen, which is essential for maintaining the skin's suppleness and youthfulness. Elastin and keratin are other synthesised proteins. For this reason, peptides are among the ingredients used in skincare products to combat skin ageing.

There are numerous varieties of synthetic peptides that can be incorporated into skincare tailored for all skin types. "Acetyl tetrapeptide-9" is one such peptide, created through acetylation. It has demonstrated the ability to mitigate the effects of ageing. Tolerated by the body, this molecule, composed of 4 amino acids (aspartic acid, glutamine, histidine, and valine), helps toorganise the fibres in the dermis. Its action is beneficial not only to improve skin firmness loss, but also to sculpt the contours of the face. Thanks to this molecule, the epidermis is strengthened, making it firm and bouncy, and the appearance of fine lines is softened.

The anti-ageing action of "acetyl tetrapeptide-9".

The skin, like all organs, is subject to ageing. This inevitable process is characterised by a loss of tissue elasticity, the emergence of wrinkles and fine lines, as well as the appearance of various surface anomalies such as brown spots, visible dilated vessels or rosacea. With age, the complexion can also become dull and pale. This ageing process is due to the alteration of the skin mechanisms responsible for cell renewal. Thus, the complexion changes and the dermis loses its elasticity. Wrinkles appear and the skin is less taut than before.

"Acetyl Tetrapeptide-9" contributes to the slowing down of this process. To better understand, it is important to know that the starting point of this molecule's function is the role played by proteoglycan. This combination of proteins and glycosaminoglycan contributes to the improvement of collagen formation. "Acetyl Tetrapeptide-9" targets a particular one, called lumican, which is involved in both the synthesis of collagen fibrils and their organisation into functional fibres. "Acetyl Tetrapeptide-9" then naturally activates the synthesis of collagen. It increases the formation of this protein in the body, which allows the skin to tighten and rejuvenate.

Acetyl Tetrapeptide-9: A skincare treatment.

Given its properties against the signs of ageing, "acetyl tetrapeptide-9" is used in many skincare products. Our densifying serum with a complex of 3 peptides notably includes this ingredient in its composition. This serum repairs the skin and provides it with density while combating skin sagging.

It is suitable for all skin types, particularly mature skin that is prone to the development of wrinkles and fine lines. To apply it, simply apply 2 to 3 drops of serum to the face, every morning and evening, while making sure to perform circular movements. Once the treatment is absorbed, you can use your moisturising cream daily to hydrate and protect your skin.


  • FREIS O. & al. Small proteoglycans in the skin: New targets in the fight against aging. International Federation of Societies of Cosmetic Chemists (2008).

  • MAIBACH H. I. & al. Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science (2008).

  • FALLA T. J. & al. Cosmeceuticals and peptides. Clinics in Dermatology (2009).

  • NOWAK I. & al. The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations—Physicochemical and release studies. International Journal of Pharmaceutics (2015).


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