
Supported by a robust scientific foundation, retinol is perceived as one of the most potent active ingredients for mitigating the signs of skin ageing. However, it presents a wide range of side effects, despite its regulated use in skincare formulas. Indeed, this retinol-induced irritation tends to occur repeatedly in individuals. Consequently, could genetic factors govern the irritation induced by the use of retinol?



For many, despite its well-known effects on skin firmness, reducing wrinkles and fine lines, or even shrinking pore size, the action of retinol can be synonymous with irritation and redness. However, this negative reputation adversely affects this component, which is considered the most comprehensive to date. Thus, the "retinol sandwich" application technique was conceived to counteract these undesirable effects. But what does it really entail? Is it a good idea?

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