In addition to the cessation of periods, approximately 80% of women experience other symptoms during menopause. Hot flushes, insomnia, stress, vaginal dryness, itching... One of the most common is an exacerbation of skin sensitivity. This can be explained by the significant hormonal fluctuations that menopausal women undergo, particularly the significant decrease in levels of oestrogen and progesterone in their bodies. These hormones play a crucial role in regulating skin function and their reduction during menopause can lead to significant changes in the skin.
Firstly, it is crucial to understand that oestrogens have an impact on the production of collagen and elastin by fibroblasts. These proteins are essential for maintaining the structure and elasticity of the skin. Furthermore, several studies have highlighted that a decrease in collagen synthesis is accompanied by a thinning of the skin, which then becomes more fragile. The decline in oestrogen levels thus leads to a decrease in the firmness and flexibility of the skin, making it more susceptible to external irritants.
Furthermore, the decline in progesterone levels leads to a weakening of the hydrolipidic film. Indeed, it is strongly suggested that progesterone upregulates the activity of the sebaceous glands, which are responsible for sebum production. Thus, a decrease in progesterone levels leads to lower amounts of sebum, which impacts the hydrolipidic film of which sebum is the main constituent. The skin then becomes more dry, more sensitive and more prone to tightness.
Finally, hormonal fluctuations during menopause can also affect the sensitivity of sensory receptors in the skin, thereby increasing the perception of pain and discomfort. This heightened sensitivity can make the skin more reactive to stimuli from external sources such as the use of certain cosmetics, temperature changes, and allergens. The immune system then tends to overreact and mobilise inflammation mediators such as pro-inflammatory cytokines, which are involved in the occurrence of redness and irritation.