Many studies highlight the connection between acne and the glycaemic index of one's diet. Theglycaemic index of a foodindicates its ability to raise blood sugar levels, that is, the concentration of glucose in the blood.
When a food has a high glycaemic index, the level of glucose will rapidly increase in the blood. In response, the pancreas will stimulate the secretion of insulin, which is a hypoglycaemic hormone (it reduces the level of sugar in the blood).
Insulinstimulates the secretion of IGF-1 (Insulin-like growth factor-1), also known as somatomedin C,which increases the levels of androgens in the blood. Androgens, through a positive feedback mechanism, also stimulate the secretion of IGF-1. Thus, both androgens and IGF-1 stimulate the secretion of sebum which is the cause of acne. In addition to stimulating the secretion of androgens, IGF-1 reduces the amount of the transcription factor FOXO1 in the cell nucleus, leading to theactivation of mTORC1 which is involved in phenomena of hypersecretion of sebum as well as hyperkeratinisation.
Note : mTORC1 is also activated by the leucine, an amino acid that makes up meat and dairy products.
Among the foods with a high glycaemic index, we can mention the white bread, potatoes, processed foods (pastries, cakes, sweets...), cooked carrots, fruit juices... The dairy products have a low glycaemic index but have powerful insulin-stimulating properties.
Thus, foods with a high glycemic index, dairy products, as well as meat, are risk factors in the development of acne.