New: A treatment designed for rosacea-prone skin

New: A treatment designed for rosacea-prone skin

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Causes rougeurs rosacée.

Rosacea: How can we explain the redness that marks the face?

The emergence of redness on the face, primarily located on the forehead, nose, cheeks, and chin, is one of the first signs of rosacea. What factors cause this redness? How can it be reduced? Learn more about this by continuing to read.

Summary
Published April 8, 2024, by Pauline, Head of Scientific Communication — 5 min read
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The manifestations of rosacea.

Rosacea is a chronic skin disease affecting approximately 415 million people. It primarily affects women, this dermatosis often appears between the ages of 30 and 50 and is mainly characterised by a widespread redness in the centre of the face. Those affected may also suffer from skin hypersensitivity and experience tingling sensations, or even burning, in the affected areas. Other symptoms, which are invisible, can occur such as hot flushes.

Rosacea is a disease initially benign but can quickly progress to more severe forms. Indeed, without appropriate management, redness can develop and the face can be affected by significant swelling, deformations, or papules. These forms of rosacea not only cause significant aesthetic damage but are also more difficult to treat. In the most severe cases, rosacea affects the eyes and causes their inflammation.

Important : To prevent mild rosacea from worsening, it is necessary to consult a dermatologist at the first signs of warning.

What is the origin of the redness that marks the face?

Redness on the face, also referred to as facial erythema when temporary or erythrosis when it becomes permanent, represents the initial stage of rosacea. Particularly noticeable on fair skin, this redness is the result of the dilation of small, fine, red or purple blood vessels on the skin's surface, which become visible to the naked eye (telangiectasias). Moreover, individuals suffering from rosacea have highly sensitive skin and a compromised skin barrier. This characteristic contributes to the visibility of the blood vessels. Several factors can explain the increase in the diameter of the capillaries.

  • Heat : an increase in temperature is the primary cause of redness. Indeed, when the TRVP1 receptors in the epidermis are subjected to a thermal stimulus, they respond by triggering a nociceptive mechanism leading to the dilation of blood vessels and de facto the onset of redness.

  • Certain foods : much like heat, capsaicin, a molecule found in chilli, bell pepper and pepper, can stimulate the activity of the TRVP1 receptor, thereby causing the dilation of blood vessels.

  • Stress : Stress is also a trigger factor for redness in the case of rosacea. Indeed, significant stress leads to the release of certain neuropeptides, such as PACAP and CGRP. These act on the blood vessels causing vasodilation, which is the origin of the blushing and persistent erythema found in rosacea.

  • The UVB rays of the sun : UVB rays interact with the TRVP4 receptors in the epidermis, which are partly responsible for the deterioration of skin tissues due to sun exposure. The stimulation of these receptors triggers nociceptive mechanisms, an alteration in the skin's structure, and the onset of redness.

  • A parasitic colonisation : a high density of Demodex, parasites that inhabit the pilosebaceous regions of the skin, can also cause redness. If we delve into the biology at work, the Demodex secrete proteases that increase the activity of PAR-2 receptors (protease-activated receptor) present in the epidermis. This activation subsequently triggers the release of TNF-α and interleukin-1 (IL-1), inflammatory agents responsible for the redness and inflammation observed in individuals suffering from rosacea.

  • Heredity : Scientists also suspect that certain yet unidentified genes are involved in the pathogenesis of rosacea and the redness it causes. One considered hypothesis is the prevalence among individuals suffering from rosacea of certain receptors involved in inflammatory mechanisms. This prevalence could be due to a high expression of the genes coding for these receptors.

How can we reduce these redness?

To date, there is no definitive treatment for rosacea. However, if you suffer from redness due to your rosacea, your dermatologist may prescribe creams or gels for topical application. These creams are formulated with active ingredients that have vasoconstrictive properties such as brimonidine, anti-inflammatory properties, like ivermectin, and antiparasitic properties, like metronidazole. It should be noted that they can be used both preventively and curatively. Laser and intense pulsed light treatments also help to reduce redness and the visibility of blood vessels by decreasing their dilation.

Some natural alternatives also help to reduce the redness caused by rosacea. Indeed, aloe vera, green tea extract, and chamomile have anti-inflammatory and antioxidant properties that are beneficial in cases of dermatosis, and their effectiveness in reducing redness has been demonstrated in several studies. Finally, daily routines such as applying a moisturising cream and a sun care product can also help to soothe the skin and prevent and reduce redness.

Sources

  • STEINHOFF M. & al. Recent advances in understanding and managing rosacea. F1000 Research (2018).

  • ALI F. & et al. Rosacea. British Journal of Hospital Medicine.(2021).

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