PRX-T33 is a biorevitalising treatment designed to deeply regenerate the skin. What is the underlying principle of this technique and how are the sessions conducted? Here is all the information you need.
PRX-T33 solution: what is this biorevitalising treatment with a peeling effect?
Summary
Published on September 18, 2025, updated on September 18, 2025, by Lilia, Scientific Editor — 7 min of reading
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What is PRX-T33?
The PRX-T33 is a bio-revitalising peel based on trichloroacetic acid, or TCA (33%), which stimulates deep cellular regeneration in depth. It also contains hydrogen peroxide (67%), which moderates the action of the TCA, enabling effective penetration without damaging the epidermis. The name PRX-T33 reflects both the composition and function of the treatment: "P" for peel (without visible desquamation), "R" for revitalisation, "X" to emphasise the innovation of the formula, and "T33" to denote the presence of 33% trichloroacetic acid.
The cell regeneration stimulation enabled by PRX-T33 allows the correction of imperfections and enhances the skin’s radiance in a non-invasive way. Thanks to its capacity to rapidly penetrate the dermis, it reduces stretch marks, scars and the pigmented spots. This treatment assists in combating the loss of skin firmness on the face, décolletage, neck or abdomen. Unlike traditional TCA peels, which are often abrasive and associated with visible peeling, PRX-T33 works at depth without damaging the skin’s surface.
TCA, a powerful chemical exfoliant, penetrates the dermis where it stimulates fibroblasts to promote the production of collagen and elastin. However, thanks to the presence of hydrogen peroxide, its caustic effect is attenuated at the epidermal level. This mechanism activates the skin’s regeneration processes without causing burns or visible peeling. TCA induces a controlled coagulation of dermal proteins, triggering a deep skin remodelling. Hydrogen peroxide, in addition to modulating TCA’s aggressiveness, enhances the penetration of active ingredients while stimulating growth factors. The kojic acid completes the treatment by targeting melanin production, unifying the complexion and reducing pigmentation spots.
It should be noted that the PRX-T33 peel can be applied to facial skin as well as to other areas of the body. This biorevitalisation technique is recommended as a complementary treatment alongside aesthetic procedures such as radiofrequency, laser therapy or hyaluronic acid injections, among others. Unlike a conventional peel, this gel can be used in any season, even on tanned skin during the summer holidays. Finally, this biorevitalisation treatment with a peeling effect is suitable for all skin types and is not photosensitising.
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Is there clinical evidence supporting the efficacy of the PRX-T33 peel?
Although few studies have investigated the PRX-T33 peel, a recent clinical trial compared several approaches to improve the atrophic scars left by acne, often difficult to treat. The researchers conducted a randomised, double-blind clinical trial involving 120 patients divided into three groups: microneedling alone, PRX-T33 alone, or the combination of both techniques. Each participant underwent four sessions at 20-day intervals, with clinical assessments of the scars. The results show that the microneedling + peel combination achieved a more significant improvement in scar appearance, as rated by evaluators, than either technique alone, suggesting the importance of combining the PRX-T33 solution with another aesthetic medicine method, at least in the case of acne scars.
| Technique used | Clinical assessment of post-treatment scars |
|---|---|
| Microneedling alone | 29% improvement |
| PRX-T33 alone | 9% improvement |
| Microneedling and PRX-T33 | 11.5% improvement |
Efficacy of various aesthetic medicine techniques in improving the appearance of post-acne atrophic scars.
Source: BEDNARSKI I. A. & al. Double-blind, randomized controlled trial comparing the use of microneedling alone vs chemical peeling alone vs a combination of microneedling and chemical peeling in the treatment of atrophic post-acne scars: An assessment of clinical effectiveness and patients’ quality-of-life. Advances in Dermatology and Allergology (2021).
How is a PRX-T33 biorevitalising peel session conducted?
During a PRX-T33 treatment session, the first step involves deeply cleansing the skin before drying it. The gel is then applied to the area to be treated, at a rate of 2 to 5 applications per session. A manual massage is performed until the treatment is fully absorbed. The final step consists of washing and rinsing the skin using a water-soaked pad. The complete protocol generally comprises 4 to 6 sessions carried out on a weekly basis, each session lasting between 20 and 30 minutes.
The skin being temporarily weakened after this type of peel, the application of a hydrating and nourishing cream is recommended twice daily, in order to restore the skin barrier, soothe any sensitivities and optimise the treatment’s effects.
Sources
WANG B. & al. Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing. The Journal of Clinical Aesthetic Dermatology (2010).
BEDNARSKI I. A. & al. Double-blind, randomized controlled trial comparing the use of microneedling alone vs chemical peeling alone vs a combination of microneedling and chemical peeling in the treatment of atrophic post-acne scars: An assessment of clinical effectiveness and patients’ quality-of-life. Advances in Dermatology and Allergology (2021).
BIRON J.A. & al. Treatment of mild to moderate facial chrono- and photodamage with a novel intense liquid trichloroacetic acid peel. The Journal of Clinical and Aesthetic Dermaotology. (2022).
SMIT R. Evaluation of the efficacy of a TCA medium peeling procedure combined with skin biorevitalization in face rejuvenation: a case series. Journal of Dermatology and Cosmetology (2024).
