Hyaluronic acid is highly prevalent in the field of skincare and is found in a large number of creams, serums and hydrating masks. However, this is not its only cosmetic use: hyaluronic acid can also be used during microneedling sessions. What is the purpose of this technique? Is it effective? Learn more here.
Hyaluronic Acid for Microneedling: How Effective is it?
Summary
Published on May 10, 2024, by Pauline, Chemical Engineer — 6 min of reading
Themes:
Microneedling: Why use hyaluronic acid?
Microneedling, also known as Collagen Induction Therapy (CIT) and Percutaneous Collagen Induction (PCI), is a minimally invasive aesthetic dermatology treatment. It can be used for various purposes: restoring skin firmness, improving its texture, reducing the appearance of acne marks and scars, stretch marks, as well as pore size. Microneedling, which can be performed on various parts of the body, requires a device containing several fine needles, typically 0.5 to 1.5 mm long, which create micro-perforations in the epidermis and/or dermis. The creation of these micro-channels promotes the release of growth factors and leads to the synthesis and deposition of collagen and elastin in the dermis. More specifically, microneedling allows for the induction of a controlled skin lesion with minimal epidermal damage and stimulates the dermal healing cascade (inflammation, proliferation and remodelling).
Most commonly, microneedling is combined with topical formulas containing one or more active ingredient(s) tailored to the patient's specific skin issue. Hyaluronic acid, due to its hydrating and healing properties, is one of the most popular choices. The micro-injuries created by microneedling enhance the skin's absorption of the gel and the effectiveness of the hyaluronic acid. Moreover, applying this active ingredient to the surface of the treatment area facilitates the glide of the microneedling device and prevents any unwanted damage to the overlying epidermis. Another potential use of hyaluronic acid in microneedling is as a carrier for the transport of molecules whose absorption by the skin is limited. Biocompatible and biodegradable, hyaluronic acid polymerscan fulfil this role and several studies have demonstrated their effectiveness.
| Study | Issue | Transported Molecule | Results |
|---|---|---|---|
| CHIU & al. (2018) | Vaccination | Ovalbumin | Persistent antibody production for 16 weeks with a single dose |
| DONG & al. (2018) | Superficial skin tumour | Gold Nanoparticles and Doxorubicin | The combination of chemotherapy and microneedling could effectively inhibit tumour growth |
| NAITO & al. (2018) | Osteoporosis | Parathyroid Hormone | Efficient delivery of PTH through transdermal route using microneedling |
| DU & al. (2019) | Psoriasis | Methotrexate | Therapeutic efficacy proportional to the dose |
| CAO & al. (2019) | Rheumatoid Arthritis | Etanercept | Bioequivalence and Increased Compliance |
| XIE & al. (2019) | Hypertrophic Scars | Bleomycin | Technique deemed effective, practical and minimally invasive for treating hypertrophic scars |
| LEE & al. (2020) | Melanoma | Glutathione | Effective Transdermal Administration of Glutathione |
How does a microneedling session with hyaluronic acid proceed and what are the risks?
Typically, microneedling is carried out in a clinic and lasts between 15 minutes and 1 hour, depending on the area to be treated. On a cleansed and disinfected skin, the practitioner applies a hyaluronic acid serum and makes several passes at different depths to reach all layers of the dermis. Depending on the length of the needle, the patient may experience varying levels of discomfort, which may or may not require the application of a numbing cream beforehand.
There are several microneedling devices available, the most well-known being the dermaroller, a cylinder covered in micro-needles. Today, we also find mechanical microneedling pens, which are more efficient. Praised for their precision in targeting areas such as the eye contour, these devices ensure a greater number of micro-perforations within the same time frame. After the session, it is recommended to thoroughly hydrate the skin, using a hyaluronic acid gel, for example.
Microneedling sessions are generally well tolerated, however, they are not recommended for pregnant women, individuals suffering from autoimmune diseases, those undergoing anti-inflammatory or anticoagulant treatment, or those with skin lesions such as acne or herpes. Furthermore, exposure to the sun is contraindicated in the week following microneedling, as this can sensitise the skin. Lastly, it's worth noting that redness and slight swelling may appear immediately after the session and can persist for a week.
Sources
ELBULUK N. & co. Microneedling: An In-depth Review. Dermatologic Surgery (2017).
GRAHAM P. & et al. Microneedling: A Review and Practical Guide. Dermatologic Surgery (2018).
CHIU Y. S. & others. Sodium Hyaluronate/Chitosan Composite Microneedles as a Single-Dose Intradermal Immunisation System. Biomacromolecules (2018).
NAITO C. & al. Self-Dissolving Microneedle Arrays for Transdermal Absorption Enhancement of Human Parathyroid Hormone. Pharmaceutics (2018).
DONG L. & co. 5-aminolevulinic acid-loaded hyaluronic acid dissolving microneedles for effective photodynamic therapy of superficial tumours with enhanced long-term stability. Advances in Healthcare Materials (2018).
DU H. & al. Hyaluronic acid-based dissolving microneedle patch loaded with methotrexate for improved treatment of psoriasis. ACS Applied Materials & Interfaces (2019).
CAO J. & al. Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment. Pharmaceutics (2019).
XIE Y. & al. Enhanced in vitro efficacy for inhibiting hypertrophic scar by bleomycin-loaded dissolving hyaluronic acid microneedles. Journal of Materials Chemistry (2019).
LEE Y. & al. Odourless Glutathione Microneedle Patches for Skin Lightening. Pharmaceutics (2020).
RAI V. K. & others. Hyaluronic acid-based microneedle array: Recent applications in drug delivery and cosmetology. Carbohydrate Polymers (2021).
