Moles are a common part of our daily lives, yet not all are harmless. Melanoma, a particularly aggressive form of skin cancer, can sometimes develop from a simple mole. However, it can be challenging to distinguish between a melanoma and a regular mole. Continue reading to learn more about the differences between the two.
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How to distinguish between a mole and a melanoma?
Summary
- Mole and Melanoma: A Brief Overview
- 1. The context of appearance differs between a melanoma and a mole
- 2. Moles and melanomas exhibit different appearances
- 3. A clinical examination by a dermatologist, the only definitive method to identify a mole or melanoma
- Sources
Published March 27, 2025,
updated on March 27, 2025,
by
Pauline, Chemical Engineer
—
6 min read
Mole and Melanoma: A Brief Overview.
A mole, or naevus, is a flat or raised spot that appears on the skin's surface. It is the result of a build-up of melanocytes in the superficial layer of the epidermis. Most moles form in response to repeated exposure to UV rays: that's why congenital naevi, i.e., moles present at birth, are so rare. They can also be triggered by hormonal changes, during adolescence or during pregnancy for example. Moles are generally benign but they should be closely monitored as they can evolve and become dangerous.
In rare instances, moles can evolve into melanoma, an aggressive form of skin cancer.
Melanomas are cancerous tumours that develop within melanocytes. They can form directly on the skin, but in 20 to 30% of cases, they form in an existing mole, according to a study conducted by STRATIGOS and his team. Heredity plays a key role in the development of certain skin cancers. A genetic mutation, often on the BRAF gene, can be the cause, leading to excessive activation of the MAPK signalling pathway, involved in cell growth. Sun exposure is also a factor in the occurrence of melanomas. Indeed, according to the National Cancer Institute, about 80% of melanomas result from excessive exposure to UV rays.
1. The context of appearance differs between a melanoma and a mole.
The emergence of a mole and that of a melanoma do not follow the same rules or timeline. The former generally form during childhood or adolescence, and their number tends to stabilise in adulthood. Some may appear later, but this is less common. It's worth noting that individuals with fair skin, eyes, or hair generally have a greater number of moles.
The situation is different for melanomas. Although they can appear at any age, the average age of their diagnosis is 60 years. That's why the late development of a pigmented lesion is something to closely monitor. However, it's important to emphasise that melanomas are not only relevant to older individuals: they remain the most common cancer in adults between 25 and 50 years in Western regions.
2. Moles and melanomas exhibit different appearances.
Even though it's not always easy to distinguish a mole from a melanoma, their appearance is slightly different. A typical naevus usually has a well-defined shape, with clear and regular edges and a uniform colour. It can be brown, black, sometimes slightly blue, but its colour is consistent across its entire surface. The surface of a mole is normally smooth, without significant texture or irregularities. Furthermore, naevi are painless and do not cause itching sensations.
Melanoma, on the other hand, has a much more heterogeneous appearance. Its borders can be poorly defined and its shape is often asymmetrical. Moreover, a melanoma can sometimes be of different colours: this chromatic diversity is indicative of an abnormal proliferation of melanocyte cells. Another sign to watch out for: a melanoma can be granular, rough or present raised areas. Some lesions may even ooze, bleed spontaneously or form a crust, which is not the case with a benign mole. Finally, unlike a naevus, a melanoma tends to evolve and grow rapidly, often beyond 6 mm in diameter. Faced with a lesion presenting one or more of these characteristics, a swift consultation with a dermatologist is essential.
Advice : To identify atypical moles that may develop into melanoma, it is advisable to refer to the ABCDE method.
3. A clinical examination by a dermatologist, the only definitive method to identify a mole or melanoma.
While self-monitoring of moles is crucial, only a dermatologist can definitively confirm whether a pigmented lesion is a mole or a melanoma.
During a consultation, the dermatologist begins with a detailed clinical examination of the skin, assessing the size, shape, colour, and texture of pigmented lesions. To delve deeper, they often use a dermatoscope, an optical instrument similar to a magnifying glass that allows the internal structures of the mole to be observed with magnification. This reveals elements invisible to the naked eye, such as vascular irregularities or structural asymmetries, which could be a sign of malignancy. If a lesion appears concerning, a biopsy is performed, meaning a skin sample is taken for subsequent laboratory analysis, under a microscope.
In the event of a confirmed melanoma, the approach relies on a surgical excision. The aim is to completely remove the tumour with a safety margin around the melanoma to limit the risk of recurrence. If the cancer is at a metastatic stage, meaning it has spread, immunotherapy or, less commonly, chemotherapy, may be performed to enhance the immune response and halt the progression of the melanoma.
Early detection makes all the difference: a melanoma diagnosed early is much easier to treat than a metastatic melanoma.
Sources
BONIOL M. & al. Reviews on sun exposure and artificial light and melanoma. Progress in Biophysics and Molecular Biology (2011).
HATZISTERGOS K. E. & al. How, and from which cell sources, do nevi really develop? Experimental Dermatology (2014).
BOSENBERG M. & al. Melanocytic nevi and melanoma: unraveling a complex relationship. Oncogene (2017).
STRATIGOS A. J. & al. A review of nevus-associated melanoma: What is the evidence? Journal of the European Academy of Dermatology and Venereology (2022).
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