Hyaluronic acid is a hydrating agent used in a multitude of cosmetic treatments. However, it can act slightly differently depending on its molecular weight and form. What are the criteria to consider when choosing a hyaluronic acid treatment? Discover our advice by continuing your reading.
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How to choose a good hyaluronic acid?
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Published May 13, 2024,
updated on May 13, 2024,
by
Pauline, Chemical Engineer
—
5 min read
Hyaluronic Acid: Which One to Choose?
The hyaluronic acid is a molecule found in the dermis, eyes, muscles, and even joints, which has the unique property of being hydrophilic. Acting like a sponge, it retains about 1000 times its weight in water. In addition to its strong hydrating power, the hyaluronic acid has healing and anti-inflammatory virtues, making it a choice active ingredient in cosmetic formulation. It is included in the composition of many skincare products under several INCI names: Hyaluronic Acid, Hydrolysed Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer... These different forms of hyaluronic acid have slightly different properties, particularly due to the difference in molecular weight of the active ingredient, making the choice of a product delicate.
Low molecular weight hyaluronic acid (50 - 1000 kDa) is capable of penetrating deep into the epidermis, where it can act as a signalling molecule for the synthesis of new endogenous hyaluronic acid molecules. In this way, it helps to hydrate skin tissue and maintain the structure of the extracellular matrix. It is recommended for people wishing to prevent or reduce the signs of ageing. High molecular weight hyaluronic acid (> 1800 kDa) remains on the surface of the stratum corneum, where it ensures hydration of the superficial layers of the epidermis and limits water loss. It is particularly appreciated by dehydrated skin, giving it a plumped, smooth appearance, even if this effect is temporary.
A recent study compared the effects of different formulations of hyaluronic acid with varying molecular weights. Over a period of 60 days, 76 women with wrinkles around the eye contour applied a 0.1% hyaluronic acid cream twice daily, with molecular weights of 50, 130, 300, 800, or 2000 kDa. The progression of various skin parameters was measured. The results are presented in the table below.
| Molecular weight of hyaluronic acid incorporated into the cream at 0.1% | Hydration | Elasticity | Gentleness |
|---|---|---|---|
| 50 kDa Hyaluronic Acid | + 15.8 % | + 13.2 % | + 8.4 % |
| 130 kDa Hyaluronic Acid | + 9.8 % | + 24.3 % | + 10.8 % |
| 300 kDa Hyaluronic Acid | + 13.8 % | + 13.0 % | + 17.7 % |
| 800 kDa Hyaluronic Acid | + 5.1 % | + 5.8 % | + 9.9 % |
| Hyaluronic Acid at 2000 kDa | + 2.9 % | + 6.9 % | + 0.4 % |
Upon reviewing this report, it appears that the active ingredients which have achieved the best overall results are hyaluronic acid at 130 kDa and that at 300 kDa. The study thus seems to suggest that low molecular weight hyaluronic acid offers more interesting cosmetic possibilities.
However, to maximise the benefits, it is generally recommended to combine high molecular weight hyaluronic acid with low molecular weight hyaluronic acid in cosmetic formulation, the ideal being to have a 50:50 ratio.
Note : Regarding injections, the preferred type of hyaluronic acid is the cross-linked form, that is, possessing a three-dimensional structure. This cross-linking allows for an extended duration of the hyaluronic acid's action as it makes it more resistant to enzymatic degradation. In aesthetic medicine, hyaluronic acid injections are primarily used to fill wrinkles, increase lip volume, redefine facial contours, and restore lost volume.
Sources
ANDRE P. Hyaluronic Acid and Its Application as a "Rejuvenation" Agent in Cosmetic Dermatology. Seminars in Cutaneous Medicine and Surgery (2004).
PAVICIC T. & al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology (2011).
DAYAN E. & al. Practical Approach and Safety of Hyaluronic Acid Fillers. Plastic and Reconstructive Surgery (2019).
SINKOROVA Z. & al. Hyaluronic Acid: Recognised for Nearly a Century, Yet Still in Fashion. Pharmaceutics (2022).
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