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Dangers utilisation ectoïne.

Are there any dangers associated with the use of ectoine in cosmetic products?

Synthesised by bacteria through fermentation, ectoine is known for its benefits. However, one must question whether there is any risk in using ectoine. Let's learn more in this article.

Published April 5, 2024, by Kahina, Scientific Editor — 3 min read

Can Ectoine be dangerous?

Overall, the scientific literature demonstrates that ectoine carries no major risk when used on the skin. Indeed, studies have shown that ectoine cosmetic formulations, whether they are used for allergic symptoms, anti-ageing properties or inflammation prevention, have not led to any adverse events or significant side effects. It is also entirely suitable for sensitive skin and does not present any particular incompatibility.

Specifically, research has found that the use of ectoine up to 7% in topical formulation displays a superb profile of tolerance and safety among adult and child populations in long-term application (up to six months). The usual and recommended concentrations of ectoine in cosmetic products range between 0.5% and 3%, we can say that the market's ectoine is safe for human use.

However, there can be instances where side effects may occur at high concentrations (7%), although these situations remain extremely rare. Among them, one may experience discomforts such as a burning sensation, tingling, redness, and an exacerbation of skin lesions. The discomfort often subsides over time. Nevertheless, it is always possible to perform a skin test by applying a care product containing ectoine in the crook of the elbow, on the inner side of the wrist or behind the ear to observe possible skin reactions if you have any doubts.

Although ectoine itself has not been directly studied in pregnant women, the overall data is reassuring regarding its safety profile. However, further research specifically on ectoine and pregnancy is necessary to obtain conclusive safety assessments. Therefore, discuss with your doctor before using products containing ectoine if you are pregnant or breastfeeding.

Please always refer to the product's user manual for more accuracy. If you experience any unusual effects or have the slightest doubt, consult your doctor.


  • TRONNIER H. & al. In vivo assessment of ectoin:
    A randomized, vehicle-controlled clinical trial. Skin Pharmacology and Physiology (2007).

  • BILSTEIN A. & al. Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: A randomised, comparator-controlled, intra-individual double-blind, multi-center trial. Skin Pharmacology and Physiology (2014).

  • KAUTH M. & al. Topical ectoine application in children and adults to treat inflammatory diseases associated with an impaired skin barrier: A systematic review. Dermatology and Therapy (2022).


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