Eczema is a non-contagious dermatosis that can significantly impact the quality of life of those who suffer from it. It is particularly responsible for red patches on the skin and intense itching. Known for its antioxidant and anti-inflammatory effects, could vitamin E help to alleviate the symptoms of eczema? Discover in this article what the scientific literature has to say.
Vitamin E: What are its effects on eczema?
Published on April 19, 2024, by Pauline, Chemical Engineer — 6 min of reading
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Vitamin E: Benefits for People Suffering from Eczema?
Eczema is a widespread inflammatory skin disease. In France, it is estimated to affect 2 million adults, which represents nearly 4% of the population. This dermatosis, which progresses in flare-ups, is characterized by pronounced skin dryness and redness, accompanied by severe itching. Fortunately, solutions exist today to alleviate and space out the flare-ups. In addition to the daily application of an emollient care on the skin, dermatologists can prescribe creams based on cortisone to relieve eczema flare-ups.
Concurrently, research continues in the quest to find new treatments, either as a supplement or replacement for dermocorticoids. Among the options being studied, vitamin E appears to be emerging as a relevant supplement in cases of eczema. Indeed, this fat-soluble molecule possesses antioxidant and anti-inflammatory properties that are beneficial in combating this skin condition. Naturally found in sebum, it protects its constituents from lipid peroxidation, a reaction that leads to the creation of compounds harmful to the skin. Moreover, this change in the composition of the sebum damages the hydrolipidic film, which is already fragile on atopic skin. The antioxidant effects of vitamin E also allow it to neutralise free radicals before they activate certain nuclear factors and lead to the release of pro-inflammatory cytokines, molecules involved in the pathogenesis of eczema.
Furthermore, some studies have shown that vitamin E can inhibit the activities of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (LOX-5). The former is an enzyme catalysing the conversion of arachidonic acid into PGE2, an inflammatory mediator causing painful sensations and itching. LOX-5, on the other hand, catalyses the synthesis of certain leukotrienes, lipids that exacerbate eczema symptoms by recruiting other pro-inflammatory cells.
These various mechanisms of action have led several scientists to study the tangible effects of vitamin E on eczema during clinical trials, conducted with volunteers affected by this skin condition. Most of the studies were carried out by comparing the SCORAD (Scoring Atopic Dermatitis) before and after treatment. This clinical tool, developed in 1993, is today the most widely used worldwide to assess the severity of atopic dermatitis. It takes into account a broad range of criteria, including the severity of lesions, the intensity of itching, and the impact of the disease on sleep, daily activities, and mood. The table below summarises the results obtained from 4 studies.
| Study | Active Ingredient(s) | Number of patients | Duration of the Study | Results |
|---|---|---|---|---|
| CLAYTON & et al. (1989) | Vitamin E (402 mg/day) and Selenium (600 μg/day) | 20 | 3 months | No improvement in eczema |
| MENCHINI & al. (2002) | Vitamin E (268 mg/day) | 50 | 8 months | Significant improvement in eczema symptoms for 80% of patients |
| MIRSHAFIEY & al. (2011) | Vitamin E (402 mg/day) and Vitamin D (40 μg/day) | 11 | 2 months | Average reduction of SCORAD by 64.3% |
| MIRSHAFIEY & al. (2011) | Vitamin E (402 mg/day) | 11 | 2 months | Average reduction in SCORAD by 35.7% |
| MOHSEN & co. (2015) | Vitamin E (268 mg/day) | 35 | 4 months | Average reduction in SCORAD by 11.12% |
Overall, studies appear to suggest that oral supplementation with vitamin E has positive effects in cases of eczema and can help to alleviate symptoms. However, it is important to emphasise that vitamin E cannot lead to a complete remission. Studies clearly show this: the average reduction in SCORAD did not exceed 40% when taking vitamin E alone. Furthermore, the initial work carried out by CLAYTON and his team did not demonstrate any effect of vitamin E on eczema, although this may be partly due to the selenium also administered to patients. It would now be interesting for researchers to investigate the effects on eczema of topical application of vitamin E, as this angle of study has not yet been explored.
If you are suffering from eczema, it is necessary to follow the recommendations of your dermatologist. Furthermore, before starting a vitamin E supplementation, we advise you to discuss it with them beforehand and certainly not to stop the treatment they have prescribed for you.
Sources
CLAYTON B. E. & others. The impact of selenium and vitamin E supplementation on atopic dermatitis. Acta Dermato-Venereologica (1989).
MENCHINI G. & al. Assessment of Vitamin E dietary intake in the management of atopic dermatitis: a study on the clinical progression and evaluation of serum immunoglobulin E levels. International Journal of Dermatology (2002).
MIRSHAFIEY A. & al. Randomised controlled trial utilising vitamins E and D supplementation in atopic dermatitis. Journal of Dermatological Treatment (2011).
MOHSEN S. & al. Effects of oral vitamin E on the treatment of atopic dermatitis: A randomised controlled trial. Journal of Research in Medical Sciences (2015).
