In which products can argireline be found?

The argireline is a biomimetic peptide composed of six amino acids capable of interacting with the neuromuscular mechanisms involved in the formation of expression lines. Classified among the peptides neurotransmitters, this molecule acts by modulating the release of acetylcholine, the neurotransmitter responsible for muscle contraction. By partially disrupting the assembly of the SNARE complex, essential for nerve signal transmission, argireline helps to reduce the intensity of repeated contractions in the forehead or around the eyes, thereby aiding in smoothing the skin.

Often compared to botulinum toxin due to this shared biological mechanism, it nevertheless differs markedly: the argireline is not injected, does not paralyse the muscle and has an excellent tolerance profile when applied topically. It acts in a gentler, more gradual way and is particularly valued for formulating treatments targeting expression wrinkles. Depending on the formulation, its concentration typically ranges from 5% to 20%.

If argireline is incorporated into various product formulations, these are exclusively intended for application to the skin, rather than to hair or the scalp.

The serums with argireline.

The serums are the cosmetic products that harness argireline most effectively, as their fluid texture allows targeted application to the areas where micro-contractions are most pronounced, notably the forehead and crow’s feet. Argireline is integrated often at high concentrations to maximise its biomimetic action on the SNARE complex, which governs acetylcholine release. The lightweight texture of serums containing argireline allows rapid absorption. They are typically applied morning and evening to clean skin, just before moisturiser, with special attention to expression zones.

The creams containing argireline.

In a cream, argireline benefits from a richer, slightly occlusive base. This type of formulation allows the peptide to be integrated directly into a daily routine targeting expression lines, while ensuring a constant supply of lipids and hydrating agents. As a moisturising cream is a skincare staple, those formulated with argireline are particularly suited to individuals seeking a minimalist routine without a serum step. They are used twice daily: in the morning before sunscreen, and in the evening as the final step of the routine.

The eye contour care with argireline.

The eye contour is one of the areas where argireline is most effective, as repeated movements (blinking, smiling...) rapidly crease the skin, which is very thin. Argireline helps to diminish the depth of crow’s feet and to prevent repeated muscle tension. The eye contour treatments are applied in small quantities—about the size of a grain of rice—morning and evening, gently tapping from the inner corner towards the temple.

The masks patches with argireline.

Certain brands offer masks containing argireline, designed to smooth expression-marked areas rapidly. These masks are used occasionally, typically once or twice a week, and are left on the face for ten to twenty minutes. They are often accompanied by patches which do not contain argireline but facilitate its occlusion. These patches create a physical barrier that reduces evaporation and enhances the peptide’s penetration into the epidermis.

Argireline ampoules.

Some ampoules concentrate argireline in a single-dose format, often combined with other peptides for immediate effect. This design eliminates any risk of external contamination, since the entire contents are used once the ampoule is opened. Argireline-based ampoules are particularly useful for short courses – from a few days to a few weeks – to give your skincare routine a boost. They are typically applied once a day, directly before serum or moisturiser.

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