The treatment of fulminant rosacea primarily relies on the use ofisotretinoin, at a dosage of 0.5 mg/kg per day. This derivative of vitamin A belongs to the retinoid family and is particularly used in cases of persistent inflammatory acne. From a mechanistic perspective, isotretinoin blocks the activity of the sebaceous glands, thereby inhibiting sebum production. In doing so, it halts the proliferation of microorganisms that feed on it.
Beyond isotretinoin, tetracyclines, a group of bacteriostatic antibiotics that also possess anti-inflammatory properties, have sometimes been used successfully. Scientists also report cases of the use of oral erythromycin, whether combined with oral corticosteroids or not, in pregnant women suffering from fulminant rosacea as isotretinoin and tetracyclines are contraindicated during pregnancy. In several studies, oral erythromycin proved to be minimally effective in controlling symptoms and isotretinoin was introduced post-delivery, which led to an improvement in symptoms.
When considering the available scientific data as a whole, it is observed that oral corticosteroids and isotretinoin are treatments of choice in cases of fulminant rosacea, unless other factors, such as pregnancy, make their use impossible. In these instances, oral antibiotics are considered, however, patients are warned that this treatment alone may not be sufficient.
Please note : while papulo-pustular lesions generally disappear within a few weeks after the start of a treatment, erythema often persists for several months.