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Profile: Acetyl Tetrapeptide-3

Commonly known as: Acetyl Tetrapeptide-3, Acetyl-KGHK peptide.
I.N.C.I. list name: Acetyl Tetrapeptide-3.
Extraction process: Acetylation reaction of Tetrapeptide-3.
Source: Synthetic.
Botanical name: /
Family: /
Part of the plant extracted: /
Provenance, origin: France.
Chemical characteristics: A peptide of 4 amino acids (Ac-Lys-Gly-His-Lys-NH2); Molecular mass: 509.6 g/mol; Optimal pH: 4.0 - 8.0; Soluble in DMSO.
Characteristics: Aqueous true solution, emulsion.
Dosage required in cosmetic products: Recommended dosage for preventive care: between 0.5 and 2.5%; Recommended dosage for intensive treatments: between 2.5 and 5%.
Function: Skin protective agent.
Properties: Anti-inflammatory, hair strengthening, hair densifying, hair regenerating.
Benefits: Recommended for preventing and combating the process of hair loss.

Details

Properties

  • Anti-inflammatory: Reducing local micro-inflammations around hair follicles by decreasing the production of the pro-inflammatory cytokine IL-8, thus mitigating the process of hair follicle miniaturisation;

  • Hair Densifier: Stimulating hair growth, increasing the size of hair follicles and making them thicker, thereby ensuring a reduction in the risk of hair loss, by inhibiting the activity of the 5-α reductase enzyme, thus modulating the level of dihydrotestosterone (DHT), the hormone responsible for baldness;

  • Hair fortifier: Helps to make hair, eyelashes, and eyebrows stronger, improves the anchoring of hair follicles, and strengthens the hair root by stimulating the renewal of proteins in the extracellular matrix of the follicle surrounding the hair papilla (collagen I and III, laminin);

  • Hair Regeneration: Ensuring improved regeneration of the hair follicle, necessary for initiating a new hair growth cycle, by preserving the activity of the dermal papilla cells.

Usage

  • Facial Care (cleansers, lash & brow boosting serums, eye contour creams);

  • Hair Care (fortifying shampoos, hair serums);

  • Makeups (mascaras).

Method of Preservation

Store in a dry place at a temperature between 0 and 4°C for short-term storage (days or weeks) or at -20°C for long-term storage (months or years), protected from moisture, direct sunlight and heat.

Contraindications, Usage Precautions

Acetyl Tetrapeptide-3 is regarded as a safe active ingredient for topical use. Even pregnant and breastfeeding women can use it.

Find out more

Acetyl tetrapeptide-3 is a biomimetic peptide composed of four amino acids, derived from a signal peptide. It possesses potent tissue-protective properties and stimulates tissue remodelling following the initial phase of healing. Used in hair care, this unique and patented active ingredient has been designed for its direct effect on the hair follicle to prevent and halt hair loss, and to stimulate hair growth. Compared to minoxidil, a well-known treatment widely used for alopecia, acetyl tetrapeptide-3 has shown comparable, if not slightly superior, efficacy, and this without the known side effects of minoxidil (irritations, etc.). It thus appears that this peptide is well on its way to becoming a competitive alternative to minoxidil and a genuine means of combating hair loss.