According to the World Health Organisation (WHO), the term "endocrine disruptor" refers to "a substance or a mixture of substances that alter the functions of the endocrine system and thereby induce harmful effects in an intact organism, its offspring, or within (sub)populations". Put simply, it is a family of compounds capable ofinteracting with the hormonal system, thereby affecting various functions of the body (metabolism, nervous system, reproductive functions...).
Endocrine disruptors can alter the hormonal system at various levels. They can interact with the synthesis, transport, mode of action, or even the degradation of hormones. Thus, the physiological changes brought about by endocrine disruptors are due to their indirect effects. The mechanisms of action of endocrine disruptors are quite varied but, most often, these substances alter the natural production of intrinsic hormones, mimic the action of these hormones by substituting for them, or prevent their action by attaching to the receptors with which they usually interact.
The origins of endocrine disruptors are diverse and the sources of exposure are numerous. Indeed, these molecules can be present in everyday objects such as household products, cosmetics, agri-food products... Endocrine disruptors are also found in the environment due to frequent contaminations of various mediums, such as water, sediments, soils, or even the air we breathe.
Note : It is important to clarify that many compounds labelled as endocrine disruptors are most often only suspected of being so. Indeed, it is very difficult to demonstrate that a substance interacts with the hormonal system, which explains why there are very few proven endocrine disruptors to date.