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Acetyl Tetrapeptide-2.

Commonly known as: Acetyl Tetrapeptide-2.
I.N.C.I. list name: Acetyl Tetrapeptide-2.
Extraction process: Chemical synthesis of peptides followed by N-acetylation.
Source: Synthetic.
Botanical name: /
Family: /
Part of the plant extracted: /
Provenance, origin: /
Chemical characteristics: Enzyme inhibiting peptide; Sequence of 4 amino acids (lysine-aspartic acid-valine-tyrosine); Peptide mimicking thymopoietin (hormone produced by the thymus); Molecular mass: 565.6 g/mol; Soluble in water; Insoluble in oil.
Characteristics: Colloidal solution, emulsion, true hydrophilic solution, gel.
Dosage required in cosmetic products: /
Function: Skin maintenance agent.
Properties: Firming, anti-inflammatory, nourishing, soothing, plumping, depigmenting.
Benefits: All skin types, particularly mature skin and skin prone to hyperpigmentation; All hair types.

Details

Properties

  • Anti-inflammatory: Boosting the skin's immune defences;

  • Depigmenting, lightening: Inhibiting the activity of tyrosinase, an enzyme responsible for the production of melanin, in order to reduce the appearance of brown spots;

  • Firming, plumping: Inducing the production of Type I collagen and functional elastin to compensate for their loss, and preventing their degradation by interfering with the enzymatic processes that break them down (metalloproteinases);

  • Regenerating: Increasing the proliferation of epidermal keratinocytes to strengthen the skin's barrier function against external factors and prevent water loss.

Applications

  • Facial Care (uniforming serums, eye serums/creams, face creams, cream-masks, lotions, gels, SPF creams);

  • Body Care (stretch mark body creams, milks);

  • Haircare (shampoos, conditioners).

Method of Preservation

Store away from light, moisture and heat.

Contraindications, usage precautions.

The acetyl tetrapeptide-2 is considered to be non-hazardous and is well tolerated by all skin types.

Find out more

Acetyl tetrapeptide-2 is a biomimetic enzyme inhibiting peptide, derived from the youth hormone. It serves to stimulate the structural elements of the skin, particularly collagen, fibrillin and elastin, and to maintain their correctly assembled levels. It also prevents collagen degradation by interfering with the enzymatic processes that break it down. Furthermore, it facilitates the union between cells and the extracellular matrix. Another study has shown that acetyl tetrapeptide-2 contributes to hair regeneration and strengthening by increasing the proliferation of interfollicular keratinocytes and improving the synthesis of structural proteins in individuals prone to alopecia. Indeed, it aids hair growth due to its catagen phase inhibiting properties. In vitro, it has been demonstrated that this peptide decreases the expression of TNF-alpha, a pro-apoptotic factor involved in shortening the anagen phase and inducing the catagen phase. Finally, acetyl tetrapeptide-2 also inhibits certain reactions in the melanogenesis process, thus reducing the appearance of pigmentation spots.