Three products for a radiant, customizable tan — without UV rays

Three products for a radiant, customizable tan — without UV rays

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Acide tranéxamique contre le mélasma.

The Results of Tranexamic Acid on Melasma

Melasma is the appearance of brown spots due to hormonal changes. Tranexamic acid, a synthetic active ingredient derived from the amino acid lysine, has demonstrated excellent results in reducing this type of pigmentation marks.

What Is Melasma?

Melasma, also known as pregnancy mask or chloasma, is a form of hyperpigmentation frequently seen in pregnant women, usually appearing as large brown areas on the face, especially on the cheeks, bridge of the nose, forehead and upper lip. Other parts of the body can also be affected, such as the stomach and forearms. It is the consequence of an excessive and localized production of melanin. There are three types of melasma:

  • Epidermal melasma which is the most superficial form with a hyperpigmentation of the epidermis;

  • Dermal melasma which affects the dermis;

  • Mixed melasma which is characterized by both epidermal and dermal melasma.

The main causes of melasma are hormonal changes during pregnancy, following the use of a contraceptive pill, hormone replacement therapy, as well as the use of certain anti-epileptic drugs or endocrine disorders (e.g. thyroid disorder). Repeated sun exposure can aggravate melasma.

How does tranexamic acid work against melasma?

Tranexamic acid has shown excellent results on melasma. Researchers have demonstrated a total improvement rate of 80.9% in 256 melasma patients after long-term (6 to 15 months) oral use of tranexamic acid. There were no obvious side effects of the treatment, except for a gastrointestinal reaction in 4.3% of patients and hypomenorrhea in 3.5% of patients. Another study conducted over eight weeks demonstrated the efficacy of taking two tablets of tranexamic acid three times a day combined with the topical use of the same active ingredient twice a day on dermal melasma.

In cutaneous application alone, tranexamic acid acts on epidermal type melasmas. Thus, according to a study conducted in 2019, a topical solution of 5% tranexamic acid is as effective as a cream containing 3% hydroquinone. Tranexamic acid is now a safe alternative to hydroquinone. As a reminder, this molecule is a bleaching agent that has been banned in cosmetics since 2001 in Europe because of its carcinogenic potential.

In Which Typology Skin Care Products Is Tranexamic Acid Used?

Our hyperpigmentation and lack of firmness serum contains 5% tranexamic acid. This care reduces and prevents the appearance of pigmentary spots of melasma type in particular, and supports the firming of the skin. The complexion is even, the skin is smoother and firmer. It also contains acetyl tetrapeptide-2, a peptide composed of four amino acids that stimulates the synthesis of key molecules involved in the support and firmness of the skin: elastin, collagen and fibrillin.

Sources

  • NAEINI F. F. & al. Topical tranexamic acid as a promising treatment for melasma. Journal of Research in Medical Sciences (2014).

  • JANNEY M. S. & al. A randomized controlled study comparing the efficacy of topical 5% tranexamic acid solution versus 3% hydroquinone cream in melasma. Journal of Cutaneous and Aesthetic Surgery (2019).

  • WANG J. V. & al. Tranexamic acid for melasma: Evaluating the various formulations. Journal of Clinical and Aesthetic Dermatology (2019).

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