Biotinyl-GHK
Is biotinyl-GHK compatible with colour-treated hair?
Yes, biotinyl-GHK is safe for colour-treated hair and does not alter the colour.
Is biotinyl-GHK safe for daily use?
Yes, biotinyl-GHK is generally well tolerated and can be used daily in hair and skin care.
Is biotinyl-GHK effective against hair loss?
Yes, this peptide is recognised for reducing hair loss by strengthening hair follicles.
What is the difference between biotinyl-GHK and biotin?
Biotinyl-GHK is the product of the reaction between biotin (vitamin B8) and tripeptide-1, a peptide composed of three amino acid residues (Gly-His-Lys).
Can biotinyl-GHK be used on eyelashes and eyebrows?
Yes, some products designed to stimulate eyelash and eyebrow growth contain biotinyl-GHK.
How does biotinyl-GHK act on the hair follicle?
This peptide stimulates the proliferation of follicular dermal papilla cells, which are essential for hair growth. It promotes cell proliferation by activating signalling pathways such as the extracellular signal-regulated kinase (ERK1/2) pathway, enhancing ERK1/2 phosphorylation. This activation leads to increased expression of genes related to hair regeneration, including vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2) and fibroblast growth factor 7 (FGF-7), all of which support the growth of hair and fur.
Can biotinyl-GHK cause ocular irritation?
Eyelash formulations are engineered to minimise this risk. Nevertheless, individual sensitivity may still occur, emphasising the importance of avoiding direct contact with the eye.
Can biotinyl-GHK be combined with other hair-active ingredients?
Yes, biotinyl-GHK is frequently combined with other peptides or vitamins. These combinations are intended to exert a complementary effect on the follicle and the fibre.
Is it possible to use products containing biotinyl-GHK during pregnancy?
There is no specific contraindication associated with biotinyl-GHK during pregnancy. Nevertheless, as a precautionary measure, it remains preferable to seek medical advice.
At what concentration is it used?
Biotinyl-GHK is typically used at concentrations ranging from 1% to 3%.
